In folk medicine Melissa officinalis is recommended for the treatment of stomach and duodenal ulcers, kidney and liver colic, dyspepsia, vomiting during pregnancy headaches, dental pain, edema and skin wounds. 
Recent studies suggest that the plant extract enhances the memory and can be effective against amnesia and Alzheimer's disease. These effects may be attributed to the AchE- Inhibitory activity or to nicotinic receptor activity. 
In vivo melissa officinalis extracts studies have shown antinociceptive, antihyperglycemic, antidepresant, anxiolytic, hypnotic and analgesic activity.
A study suggest that Melissa officinalis extract may be considered as a candidate for the development of oral/topical photoprotective ingredients against UVB-induced skin damage. 
Melissa officinalis and its extracts have been frequently reported as possessing bioactive properties, offering the potential for use in development/enrichment of food products with additional functional capabilities, providing health benefits to consumers. Lemon balm extract rich in rosmarinic acid can provide advantageous functional properties to bakery products. 
 UNIVERSITY of IOANNINA SCHOOL of HEALTH SCIENCES FACULTY of MEDICINE Department of Pharmacology, Medicinal Herb, Melissa officinalis.
 M. Soodi,1,* N. Naghdi,2 H. Hajimehdipoor,3 S. Choopani,2 and E. Sahraei1: Memory-improving activity of Melissa officinalis extract in naïve and scopolamine-treated rats. Res Pharm Sci. 2014 Mar-Apr; 9(2): 107–114. PMCID: PMC4311288PMID: 25657779.
 Gabriela Petrisor, Ludmila Motelica, Luminita Narcisa Craciun,4 Ovidiu Cristian Oprea, Denisa Ficai, and Anton Ficai: Melissa officinalis: Composition, Pharmacological Effects and Derived Release Systems—A Review. Int J Mol Sci. 2022 Apr; 23(7): 3591. Published online 2022 Mar 25. doi: 10.3390/ijms23073591 PMCID: PMC8998931PMID: 35408950
 Almudena Pérez-Sánchez, Enrique Barrajón-Catalán, Maria Herranz Lopez, Julián Castillo, Vicente Micol: Lemon balm extract (Melissa officinalis, L.) promotes melanogenesis and prevents UVB-induced oxidative stress and DNA damage in a skin cell model. August 2016Journal of Dermatological Science 84(2) DOI:10.1016/j.jdermsci.2016.08.004. Project: Polyphenols and skin protection.
 Caleja C, Barros L, Barreira JCM, Ciric A, Sokovic M, Calhelha RC, Beatriz M, Oliveira PP, Ferreira ICFR. Suitability of lemon balm (Melissa officinalis L.) extract rich in rosmarinic acid as a potential enhancer of functional properties in cupcakes. Food Chem. 2018 Jun 1;250:67-74. doi: 10.1016/j.foodchem.2018.01.034. Epub 2018 Jan 4. PMID: 29412929.
* Please, note that the above statements are summaries of published studies and and investigations as cited at the end of each statement.
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