CO2 Total Extract
Botanical name: Matricaria chamomilla
Common name: Chamomile
Geographical position: 700m above sea level
Part of the plant used: Flower (wild)
Appearance: Dark Brown solid.
Major compounds: Farnesene, bisabolol, spiroether
Odor: Natural and fresh fragrance
Matricaria chamomilla a.k.a German chamomile shows antipruritic effect in vivo when administered in oral routes in mice. Its antipruritic effects support anti-allergic properties of other agents. It also enhances the antipruritic effect of antihistamine. The enhanced antipruritic and anti-allergic effects achieved when typical antihistamines are combined with Matricaria chamomilla extract suggest a more comprehensive therapeutic approach. 
Matricaria chamomilla is also rich in antioxidants which is a property found beneficial in cosmeceutical formulations that promote healthy skin by reducing oxidative stress. A daily application during a 4-week period resulted in a more hydrated skin, the top layer of epidermis. Other than increasing the water content in stratum corneum, Matricaria chamomilla extract constituents seem to have bonded to free radicals, thus reducing oxidative damage to skin. 
Added in mouthwashes, 1% Matricaria chamomilla extract shows anti-inflammatory effect in both preventing and soothing oral mucositis in hematopoietic stem cell transplantation patients. The anti-inflammatory effects observed were successful and were accompanied with no adverse effects. 
 Kobayashi, Yoshinori & Takahashi, Ria & Ogino, Fumiko. (2005). Antipruritic effect of the single oral administration of German chamomile flower extract and its combined effect with antiallergic agents in ddY mice. Journal of ethnopharmacology. 101. 308-12. 10.1016/j.jep.2005.05.003.
 Nobrega, Ananda & Wagemaker, Tais & Campos, Patricia. (2013). Antioxidant activity of Matricaria chamomilla L. extract and clinical efficacy of cosmetic formulations containing this extract and its isolated compounds: Actividade antioxidante do extracto de Matricaria chamomilla L. e eficácia clínica de formulações cosméticas contendo este extracto e seus compostos isolados. Journal Biomedical and Biopharmaceutical Research. 10. 249-261. 10.19277/BBR.10.2.69.
 Braga FT, Santos AC, Bueno PC, et al. Use of Chamomilla recutita in the Prevention and Treatment of Oral Mucositis in Patients Undergoing Hematopoietic Stem Cell Transplantation: A Randomized, Controlled, Phase II Clinical Trial. Cancer Nurs. 2015;38(4):322-329. doi:10.1097/NCC.0000000000000194
* Please, note that the above statements are summaries of published studies and and investigations as cited at the end of each statement.
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