Updated: Jul 30
Here are the active principles that make it the raw material for the manufacturing of natural medication for muscle pain relief and joint inflammation relief.
What is it?
Chili Pepper CO2 Total Extract, otherwise known as Capsicum annuum Oleoresins is a product rich in the natural compounds of Chili Pepper fruit, compounds which are gently pulled from the fruit without compromising their molecular integrity and direct benefits in health and wellbeing.
Only Extracts produced by SCFE (Supercritical Fluid Extraction) Technology where CO2 at high pressure plays the role of the trace-free solvent can be considered CO2 “Total” extracts. This is due to the technology behind the process that allows for the extraction of the full spectrum of these compounds, without segregating these compounds based on their molecular mass, a phenomenon that occurs in lower pressure processes.
What are its compounds?
Due to certain factors, such as the SCFE Technology at Esencial®, the application of this technology with infrastructure and professional staff trained in compliance with International Standards of Good Manufacturing Practices ISO 9001: 2015 and choosing only 100% Natural dried medicinal plants, CO2 Total Extract of Chili Pepper is produced with superior quality, as supported by quantitative and qualitative analysis by in-house Esencial® Laboratory, while maintaining its 100% Natural characteristic (Natrue-certified soon).
Chili Pepper Oleoresins produced by Esencial® are rich in:
Capsaicinoide 15% as major compounds.
Within the Capsaicinoid group, there are:
and other minor capsaicinoids stand at about 2.8%
(may vary slightly)
Applications in the Medical and Pharmaceutical Industry
Take a look at some of the applications of the 100% Natural Active Principles of Chili Pepper Oleoresins and the Advantage over Lab-synthesized principles.
The use of Chili Pepper (capsicum annuum) Oleoresins as active principles in the production of natural topical analgesic drugs (painkillers)
Pain is a complex neuronal perception.
In short, the sensation of pain is perceived by the action of Pain Receptors or Nociceptors (nocere- to cause harm, to hurt (lat.))
Polymodal nociceptors are the most refined type of these receptors, which allow pain to be perceived regardless of the cause: mechanical, chemical, thermal, or combined.
Capsaicin manages to lower the threshold of pain perception precisely at this multifaceted level of pain through topical application of pharmaceutical preparations containing this active principle.
According to a study, the pain relieving effect of Capsaicin applied in the form of a patch with a concentration of 8% for 60 minutes had a soothing effect lasting up to 12 weeks on patients with neuropathic pain. 
Advanced classes of medications like Opioid analgesics work similarly, but with oral administration and always under strict medical supervision.
The use of Chili Pepper (capsicum annuum) Oleoresins as active principles in the production of natural anti-inflammatory drugs for joints
Joints are able to "perceive" the pain as well.
When it comes to pain mechanism regarding articulations, the pain perception threshold is rather high for the message to be communicated to the brain.
In this mechanism, pain is perceived as a sensation at the moment when neuropeptides are released from the nerve endings of these receptors.
It is precisely the release of neuropeptides that trigger the “pain mechanism” which manifests itself externally as inflammatory arthritis pain.
Capsaicinoids again act at a sophisticated chemical level by reducing the production and perception of neuropeptides.
This allows the perception of pain to be reduced and not to cause anxiety, panic, stress or physical inability to the affected person.
In a case study case of 6 patients suffering from osteoarthritis, Capsaicin (0.001 gr) was injected on the knee to provide pain relief and it was observed to significantly relieve the pain, an effect that lasted for up to 5 weeks. 
The premise of Chili Pepper (capsicum annuum) Oleoresins application as active principles in the production of topical compounds that support Collagen type I
Type I collagen is a characteristic of healthy, supple, toned and timeless skin.
The Capsaicinoid complex, especially Capsaicin, plays a vital role in protecting Type I Collagen molecules.
The molecular structure of Collagen type I is always prone to UV rays energy damage, causing oxidative degradation by breaking peptide bonds.
This phenomenon is known as "photoaging".
Formulations that are rich in natural Capsaicin, when administered topically such as on your face and neck, may:
• significantly reduces damage to the molecular structure of Collagen type I
• stimulate the production of Collagen in fibroblasts, cells which are found in the skin dermis
According to an in vivo and in vitro study, it was found that the damage caused by UV radiation to the skin at fibroblasts level where Collagen is produced could be reduced if Capsaicin was previously applied, making it an important ingredient in anti-aging cosmeseutical products. 
These are just some of the applications of Chili Pepper Oleoresins after differentiation of their active principles, focusing on the Capsaicinoid group.
For more detailed information on CO2 Total Extracts produced by Esencial® you are welcome to reach us anytime through the Chat section on our webpage or through the contact forms displayed there or on social media.
 Anand P, Bley K. Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch. Br J Anaesth. 2011;107(4):490-502. doi:10.1093/bja/aer260
2005, Chili Pepper, Botox Injections Help Ease Pain
Capsaicin Injections Soothe Osteoarthritis; Botox Helps Many Types of Pain
By Denise Mann, Medically Reviewed by Michael W. Smith, MD, WebMD
AUTHOR=Wu Qiyun, Bai Panzhu, Guo Hongsheng, Guo Maggie S. S., Xia Yingjie, Xia Yiteng, Gao Xiong, Wang Xiaoyang, Wu Jiahui, Dong Tina T. X., Tsim Karl W. K.
TITLE=Capsaicin, a Phytochemical From Chili Pepper, Alleviates the Ultraviolet Irradiation-Induced Decline of Collagen in Dermal Fibroblast via Blocking the Generation of Reactive Oxygen Species
JOURNAL=Frontiers in Pharmacology
*Disclaimer: Please note that the applications suggested and mentioned in the article are drawn from literature and published studies as referred to and cited with links and not from tests or analysis performed by Esencial®.